@article{dijokaite-guraliuc_rapid_2023,
 abstract = {In November 2021, Omicron BA.1, containing a raft of new spike mutations, emerged and quickly spread globally. Intense selection pressure to escape the antibody response produced by vaccines or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection then led to a rapid succession of Omicron sub-lineages with waves of BA.2 and then BA.4/5 infection. Recently, many variants have emerged such as BQ.1 and XBB, which carry up to 8 additional receptor-binding domain (RBD) amino acid substitutions compared with BA.2. We describe a panel of 25 potent monoclonal antibodies (mAbs) generated from vaccinees suffering BA.2 breakthrough infections. Epitope mapping shows potent mAb binding shifting to 3 clusters, 2 corresponding to early-pandemic binding hotspots. The RBD mutations in recent variants map close to these binding sites and knock out or severely knock down neutralization activity of all but 1 potent mAb. This recent mAb escape corresponds with large falls in neutralization titer of vaccine or BA.1, BA.2, or BA.4/5 immune serum.},
 area = {Virus Evolution},
 author = {Dijokaite-Guraliuc, Aiste and Das, Raksha and Zhou, Daming and Ginn, Helen M. and Liu, Chang and Duyvesteyn, Helen M. E. and Huo, Jiandong and Nutalai, Rungtiwa and Supasa, Piyada and Selvaraj, Muneeswaran and de Silva, Thushan I. and Plowright, Megan and Newman, Thomas A. H. and Hornsby, Hailey and Mentzer, Alexander J. and Skelly, Donal and Ritter, Thomas G. and Temperton, Nigel and Klenerman, Paul and Barnes, Eleanor and Dunachie, Susanna J. and {OPTIC consortium}, and Roemer, Cornelius and Peacock, Thomas P. and Paterson, Neil G. and Williams, Mark A. and Hall, David R. and Fry, Elizabeth E. and Mongkolsapaya, Juthathip and Ren, Jingshan and Stuart, David I. and Screaton, Gavin R.},
 date = {2023-04-25},
 doi = {10.1016/j.celrep.2023.112271},
 issn = {2211-1247},
 journal = {Cell Reports},
 keywords = {Amino Acid Substitution, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Antibody Formation, COVID-19, CP: Immunology, CP: Microbiology, Humans, SARS-CoV-2, SARS-CoV-2, BA.2, variant, mutation, RBD, antibodies, binding site, breakthrough, neutralizing, structure, COVID-19},
 language = {eng},
 month = {April},
 number = {4},
 pages = {112271},
 pmcid = {PMC9988707},
 pmid = {36995936},
 title = {Rapid escape of new {SARS}-{CoV}-2 {Omicron} variants from {BA}.2-directed antibody responses},
 volume = {42},
 year = {2023}
}