Microbial evolution
Richard Neher
Biozentrum, University of Basel
slides at neherlab.org/201806_Paros_lightning.html
Within-patient HIV-1 evolution
Mutation dynamics
Fitness landscapes
- accurate frequency data across the entire genome
- replicating virus and integrated reservoir
- substantial reversion towards consensus
- → core fitness landscape
Influenza virus evolution
Lost of reassortment
Crude antigenic assays
