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Kinetic accessibility of buried DNA sites in nucleosomes.

Wolfram Mobius, Richard A. Neher and Ulrich Gerland

Physical review letters, vol. 97, 208102, 2006
10.1103/PhysRevLett.97.208102

Abstract

Using a theoretical model for spontaneous partial DNA unwrapping from histones, we study the transient exposure of protein-binding DNA sites within nucleosomes. We focus on the functional dependence of the rates for site exposure and reburial on the site position, which is measurable experimentally and pertinent to gene regulation. We find the dependence to be roughly described by a random walker model. Close inspection reveals a surprising physical effect of flexibility-assisted barrier crossing, which we characterize within a toy model, the "semiflexible Brownian rotor."


Publication date

Jan 25, 2006
10.1103/PhysRevLett.97.208102
Jan 25, 2006

bibtex

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